Happy New Year

It’s that time of year when we make resolutions for the coming year.  We look at ourselves with a fresh pair of eyes, we are honest with ourselves and we decide what we would like to change.  Here are mine for 2020:

New Year Resolutions

Do we achieve our resolutions?  Sometimes…  One year I vowed not to miss a birthday and get cards for all my friends and family.  I managed that one.  Another year I vowed to do a handstand every day.  I lasted until mid-February.

We can make resolutions at work too.  We want to be more effective, especially in technically demanding Omics.  How can we do this?  Where are we less than effective?

A fresh pair of eyes in Omics… the problem

As described during a lively presentation, Prof Don Jones cites the ‘Valley of Death’.  The slide below questions how effective we are in producing clinical success, considering our extensive research efforts in plasma proteomics.

There are some successes, although not many considering the amount of research funding that has gone into Biomarker Discovery.  You can click on the image to get his full presentation.

Proteomics biomarker discovery doesn’t work??

Slide from Novel strategies for discovery of cardiovascular biomarkers in human plasma – Donald JL Jones, Leicester Cancer Research Centre, RKCSB, University of Leicester, UK

Pre-analytical variation (or biological variance) is a huge problem with clinical data and can make it very difficult to find biomarkers even from large scale discovery Omics experiments. However, the powerful co-detection workflow of Progenesis eliminates missing values, maximising the statistical power of the experiment and increasing the ability to find the real biomarkers.

It’s interesting to see poor experimental design in there, we can do something about that!  Progenesis helps you to understand the power needed in your experiment and easily lets you alter your experimental design so that you can compare the same ions in many different ways.

Don also mentions how Progenesis QI for proteomics has made a huge difference to the Department’s research.  Nice to hear!

A fresh pair of eyes in Omics…  part of the solution

This is where the New Year’s Resolution comes in…

Progenesis can truly make a difference to the success of your research project.  This is because it analyses ALL of your data – no ‘holes’, no missing values messing up your statistical conclusion.

We are seeing it being used in success stories, such as this Nature Scientific report, discussing how dietary modification using a snack made from Eurotium cristatum fermented okara (ECO) can help reduce Type 2 diabetes mellitus (T2DM).

It’s a really neat piece of work done at the International Food and Water Research Centre, IFWRC, which was opened by Waters in Singapore to advance innovative research in the food and water industries by creating a collaborative laboratory facility for both industry and academia to solve their mutual challenges.

So, have you made your work New Year’s resolutions yet?  Why not make one to try out Progenesis QI or QI for proteomics and boost your project’s chances of success?

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