If you attended ASMS 2016, you may have been lucky enough to see a preview of Progenesis QI for proteomics v3.0, and today I’m pleased to announce that it is now available to download. This release is focussed on peptide level information, with a few other treats as well.
- Improved access to peptide level information: ions are now charge-state deconvoluted so you can see whole peptide quantitation and expression profiles at Review Proteins; there is also a new peptide export available. Progenesis QI for proteomics now displays a correlation score for peptides and peptide ions which can be used to focus in on modified peptides, as well as to aid confidence with identifications. We’ve also added a new modification quick tag for peptide ions.
- Improvements to responsiveness
- Resolve conflicts is no longer part of the main workflow: following the implementation of Hi-N in v2.0 which handles conflicts by distributing the ion abundance, and based on customer feedback, we have taken the Resolve Conflicts screen out of the main workflow. You can still access this screen from Identify Peptides, in the same way that Normalisation can be reviewed or altered from Filtering.
- Support for ProteinPilot v5.0: continuing with our multi-vendor support, we have released a plugin to allow import of peptide search results from v5.0 of ProteinPilot from SCIEX.
Other minor improvements / bug fixes
- The mzML importer now supports indexed files.
- Software no longer crashes when connection to an external drive is lost (issue was limited to experiments saved externally).
- Improvements to peak picking for low intensity peptide ions, and heavy peptide ions (those with a mass greater than 3000Da).
- Other minor bug fixes.
Where can I download it?
If you’re an existing customer with an up to date coverwise plan, this upgrade is totally free of charge and very simple – you will receive an email with a direct download link as well as specific instructions on how to upgrade your dongle. In addition, if your Progenesis PC is connected to the internet, there should be a message in the Experiments list sidebar notifying you of this new version – if you click this, and your dongle is plugged in, you’ll be sent to the download page.
If you’re thinking of trying Progenesis QI for proteomics for the first time, you can download the software from here.
How will I know how to get the most out of the new features?
We’ve expanded our FAQs to cover the new features, as well as updating any previously available FAQs to correctly reflect new behaviour.
We’ve also updated our user guide if you’re looking for a step-by-step guide from start to finish.