Author Archives: Dave Jackson

Barking up the right tree: characterising Garcinia buchananii extracts with Progenesis QI

A look at how Progenesis QI helped Dr Timo Stark of Technische Universität München to rapidly characterise Garcinia buchananii extracts.

Spectral counting: why not?

One of the key considerations in bottom-up label-free proteomics analysis is the means of feature quantitation. Being peptide ions, measurements of these features are ‘rolled up’ into inferred proteins, but two main approaches can be taken to generating the data for this purpose. The first, and most commonly used, approach is MS1 (precursor-based) measurement such […]

Have you read these 21 must-read proteomics articles?

At Nonlinear we get a lot of questions on the whole analysis process for proteomics data, from experimental design through to statistical analysis, QC, and database searching for protein and compound identities. For our own software and approaches, you may well find the answers to questions you have in our FAQs, and we’re always happy […]

Structural biology with Progenesis: Hybrid Vigour

We recently published a blog in which Progenesis QI was being turned to new uses (in food standards); I’m happy to say that we can now say likewise for Progenesis QI for proteomics, this time in structural biology! A 2014 publication in Nature Methods (Argyris Politis and Florian Stengel et al., [1]) described the development […]

Progenesis QI turns food standards detective

Mass spectrometry and the multivariate statistical visualisations in Progenesis QI are being applied to adulteration testing of Basmati rice,

QC Metrics: Helping you make the most of your time

Proteomics as a field is rapidly maturing; there is a real sense that established techniques are being improved, and excitement at emerging techniques for quantitation. Central to this revolution is the application of effective quality control (QC) – understanding what adversely affects proteomics data, monitoring for problems, and being able to pin down and address […]